same filter;
As far as vampires go, think super in regards to several things - strength, hearing, speed, etc. It's the older vampires that are the biggest concern in trying to fight them, as they are much faster, stronger and controlled than the younger ones. You can tell they're the older ones by the way they move, because they know what they're doing after all those years.
Young vampires are relatively easy to kill if you can handle yourself (and sometimes even if you can't), because they're erratic and very rash. If they're annoyed or angry, they will just rush you, usually leaving themselves wide open so you can drive a stake right into their chests. That's what the biggest population of vampires in this city are, they're kind of like cockroaches.
The stake is your best bet, but if you're capable of beheading something, that works just as well. Fire is also pretty effective (and sunlight, but they know to avoid that). Holy water and crosses are useful as part of an attack or defense, but neither will do the damage necessary to dust a vampire.
Beheading and fire are also a good catch all for demons, but the best defense in those situations is to either know what you're fighting or get away, because you never know when they'll have retractable poisoned claws or acid spit or a million other lethal defenses.