Sam held out his hand in a way that suggested that he wanted for her to shake it. "Hi. I'm Sam Winchester. Also known as the guy who may potentially be the next anti-christ." Not that he planned on ever letting that happen or anything.
"If there's anything out there trying to get you, there's about twice as many aiming for me. Chances are we're better off together anyway. And if you're crazy? I don't know what the hell to call my brother."