No, I think it'll stick around. Rick's created an entire lab somewhere — somewhere, no one knows — that's stored all his stuff. Peaslee Theater still has all the changes we've made to it. There's a clearing in the woods that wasn't there before. There's a stable that some people built here for some of the larger animals that have arrived. As long as you're not screwing with the void — including time or space — it seems to be okay.
Well, we do have Rocket and Caduceus who aren't exactly human-like in visage.