My Name is Earl doesn't have a laugh track, does it?
Cheers did, though.
Many of the characters in Wonderfalls had hourly-type jobs, including the main character, Jaye. She had a bachelor's degree in Philosophy or English or something like that, and she worked in a t-shirts & souvenirs shop at Niagara Falls. It was never entirely clear whether there was really something supernatural going on or whether she was just crazy, so I think it escapes the sci-fi/fantasy restriction.
Most of the characters on Reaper work at a big-box hardware store, but most of the plots have to do with The Devil -- so, sci-fi/Fantasy.
Part of the thing about class is that most people's families have more than one class in them, in real life. Both my grandfathers were carpenters -- the building trade would count as working class, wouldn't it? But my parents' generation includes schoolteachers, newspapermen, military officers, a car salesman, a banker, and a phone company executive. Those are mostly middle class. My generation of the family has a couple of engineers, a military officer, a librarian, a school custodian, a professional artist, a city councilwoman, two business executives, and a handful of nurses. Again, kind of mixed.
One of the taglines for Chuck is "Saving the world at $11 an hour", which implies that the main character has some sort of hourly job. I only watched it about twice, though, and all I could tell you is that there were some kind of mean spies, and one of them was played by the guy who used to play Jayne on Firefly.