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East Side/West Side (1963-64)Wonderful show ran one season dealt with problems in the New York social work system. Stellar cast Cicely Tyson and George C. Scott.
I'll Fly Away (1991-1993)Takes place in The South during the begining of the Civil Rights era dealt with both race and class issues not to mention gender.
Honorable mention Naked City a cop show but the cases were diverse and the cops didn't wear Armani