"No, I know she can handle herself, Mom. Sometimes she seems like she's really grown up, when she's not spouting her mouth off. But she's my baby sister. I just want to keep her far away from any of the trouble. Hell, I barely even want the cousins in the middle of it, but with Prue I feel more personally responsible."
It was the same way with everyone he loved. Chris did not want them to be put in danger. Even if they could handle themselves because you never knew what could happen.