Barry and Caitlin
It was a good question. Barry didn't know the answer. He couldn't get drunk, but that could have been because of his specific metahuman abilities, not just because he happened to be a metahuman.
"Yeah," he said, grinning a little. "I might not be saving you this time, though. You can get up there yourself this time."
Of course, if she actually did go up there and get drunk and start singing dreadful karaoke, he'd be up there with her like always. That was what friends did. They supported each other, even when they were being stupid or drunk.