Sam Winchester & Sue Storm
"Does it now?" Sam kept the chuckle to himself. Mostly because it wasn't an amused one. His dad had kicked him out, told him not to come home again if he pursued going to college. He'd walked out the door, and hadn't looked back. At least not until Dean showed up with a story about Dad being missing, and then Jess died and Sam was effectively pulled back into the life. Yeah, there was nothing amusing to him about Dean putting his family first, or the fact that Sam going to Stanford had been unacceptable.
"He's good people, don't get me wrong. but he's my brother, so it's my job to give him crap, you know?" It might have been a cop out, but it was better than some of the things Sam could have said.