Oh there are entire schools of philosophical pessimism. Jacobi takes down Kant's rationalism essentially to a form of nihilism, though most critics think he took the analysis rather too far, kind of reductio ad absurdum.
Wittgenstein argues that truth is less about getting it right and more a justification game of language and experience that guides the answer in the direction we secretly want it to go.
However, the problem with these more nihilistic schools is that they tend to be rather anti-social and individualistic rather than consideration of ethics and moral philosophy. This isn't a matter of what might benefit each of us individually, but overall as a group.