Hi Becca, it's nice to meet you and thanks for the welcome. =)
I agree, that would be an interesting dynamic if the Longbottoms were the Aurors who brought Damon and Cyrus in. I am in as long as Manda is! Isadora definitely knows Florence but I'm not sure if they'd get along either.
It's probably best to let Florence and Isadora's relationship unfold in-game. Isadora thinks music is a stupid pursuit XD and if the pacifist thing is known, she might hold that against Florence too. And we'll definitely have to see how appropriate the "good bit of fun" is becaus4 Isadora is picky. Points for being courted by a Lestrange though!
We could figure out the relations between Betty and Isadora if you'd like. Perhaps Caractacus could be Isadora's mother's uncle or father and they could end up being cousins somehow? If Betty's a blood traitor it could be interesting seeing Isadora deny her existence and their relation.
As for the others, I don't think they'll really be in touch too much. Perhaps if Hestia has to investigate Isadora's family or something in the future?