It's not hard if that's what you mean... any bozo can do it with some practice. Just a matter of hitting the right spot before you get your throat ripped out. [ A generalized answer. Don't worry, there'll be reassurance. ]
That doesn't mean it's easy to kill me. I've taken out two Slayers. Most vampires who cross paths with a Slayer won't live to see another night, let alone get a good hit in.