Hey Laura! Hope work is good for you today! Links are overrated anyway. ;)
Rupert/Nina/Sam should all def become friends. Sam's mostly an ER nurse, but I imagine the ER in Dunhaven isn't all that busy most of the time. So I'm sure she pops around to other areas of the hospital to help where she can. She's pretty fond of kids, so peds will definitely be first up on her list.
I honestly remember almost nothing from when I tried Sam initially, (it was a weird time for me) but I am 100% good with her and Quincy being friends. Sam will need all the friends she can get.
Jack and Elle should absolutely be friends. Maybe they went on like a coupld of dates forever ago and just ended up being really good buds instead. He will come visit her at the Pourhouse frequently.