So Claire will be all about protecting her patients which is currently.... Everyone. But also understands if she gets mauled by a werewolf there isn't anyone to help her or anyone to help everyone else? Most likely she'll stick with her big cute spider friend and set up a triage somewhere for injuries.
Steve. Well. He'll be running right at that Werewolf waving his arms and sticking with Sirius on this one helping with distraction and protection.
Gamora will only go for it if it goes for her team (Nebula, Quill, Thor, Tony etc) and then she'll go hard.
Bill gets a blinding migraine if he uses magic and throws up, can't look at the light and is in utter agony and can't see to use his magic then. But he will use it to protect people - those people are probably Klaus and Ben I'd say.