Well, Albus would be like, eh. He would know Caleb from Quidditch, but that's about it.
Isadora, on the other hand, would adore him. She's sort of a hardass, proper, stuck-up and arrogant. They're both pure-blood, so perhaps they know eachother outside of school, and they're both sixth year slytherins sooo, what do you think? Friends?