The way I work it out is: nothing serious is going to happen to Osborn in a side book like this, while theoretically Maria could go down. So I'd cheer for Osborn to do the world some good by taking Maria Hill out before he gets squashed.
Sadly, I think Fraction is pretty wedded to his "Maria Hill is a fabulous hero!" thing, so undoubtedly she'll get to show Osborn up instead. But hey, there's a small hope Fraction might try to make her a martyr.