Wow. Perez really got high school. The little social nuances that he included really sucked me in. I particularily enjoyed the bit about how Nessie was so insecure over being flat-chested. It's an issue that affects a lot of girls (I'm 16 and my friends still tease me about "not hitting puberty"), but for some reason doesn't get a lot of coverage (beyond jokes or parody) in most forms of media. I think it might be because of the completely unrealistic standards the women who are cast/drawn set. It's rare to see anything smaller than a B-cup even in teens in movies, comics, or television.
Also, this was one of the best examples of a story about suicide I've ever read. It was realistic, but not so much it polarized the audience and made the person who did it unsympathetic.
I love how this is a comic that really doesn't have a lot of action or fighting, or even the title character. I wish more comics did these quiet, introspective stories on occasion nowadays.