She'd probably know Al, yeah - their parents, and him being an Avenger definitely make that plausible. They could have met up on some of his travels, too, if he would've gotten in touch with her.
I think she probably knows who Kareem is, and we can say they've at least met before, but it doesn't seem like they'd have a ton of reason to be super familiar.
Oh Peggy. Amani actually dated your big brother for a while, back in high school. So she totally knows you. I'm pretty sure Amani and Owen have remained friends, so she probably keeps tabs on Peggy in a roundabout, Facebook sort of way. I think she admires her for being so visible and independent, and keeps all other opinions to herself because that's the way she does it, haha.